› 5ckq

X-ray diffraction
3.7Å resolution

CUB1-EGF-CUB2 domains of rat MASP-1

Released:
DOI: 10.2210/pdb5ckq/pdb
PDB entry 5ckq coloured by chain, front view.
PDB entry 5ckq coloured by chain, side view.
PDB entry 5ckq coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Nan R, Furze CM, Wright DW, Gor J, Wallis R, Perkins SJ
OpenAccess logo Structure 25 364-375 (2017)
PMID: 28111019

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183968 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mannan-binding lectin serine protease 1 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.89 KDa
Source organism: Rattus norvegicus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q8CHN8 (Residues: 25-301; Coverage: 41%)
Gene names: Crarf, Masp1, Masp3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 3 x CA
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: I23
Unit cell:
a: 152.71Å b: 152.71Å c: 152.71Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.248 0.294
Expression system: Cricetulus griseus

Quick links

Citations

2 review citations

Complement in neurological disorders and emerging complement-targeted therapeutics.
Dalakas et al. (2020)
1 more

1 mention without citation

Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Nan et al. (2017)