› 5cv0

X-ray diffraction
1.9Å resolution

Crystal structure of N-terminal truncated human B12-chaperone CblD (108-296)

Released:
DOI: 10.2210/pdb5cv0/pdb
PDB entry 5cv0 coloured by chain, front view.
PDB entry 5cv0 coloured by chain, side view.
PDB entry 5cv0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.
Yamada K, Gherasim C, Banerjee R, Koutmos M
J Biol Chem 290 29155-66 (2015)
PMID: 26364851

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-574363 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cobalamin trafficking protein CblD Chains: A, B
Molecule details ›
Chains: A, B
Length: 192 amino acids
Theoretical weight: 21.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9H3L0 (Residues: 108-296; Coverage: 64%)
Gene names: C2orf25, CL25022, HSPC161, MMADHC, My011
Sequence domains: Methylmalonic aciduria and homocystinuria type D protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 47.638Å b: 67.111Å c: 66.219Å
α: 90° β: 110.54° γ: 90°
R-values:
R R work R free
0.188 0.186 0.227
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Influences of the Gut Microbiota on DNA Methylation and Histone Modification.
Ye et al. (2017)
5 more

3 mentions without citation

Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.
Yamada et al. (2015)
2 more