› 5cxy

X-ray diffraction
2.15Å resolution

Structure of a Glycosyltransferase in Complex with Inhibitor

Released:
DOI: 10.2210/pdb5cxy/pdb
PDB entry 5cxy coloured by chain, front view.
PDB entry 5cxy coloured by chain, side view.
PDB entry 5cxy coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Volkers G, Strynadka NCJ

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-519957 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 323 amino acids
Theoretical weight: 37.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O43173 (Residues: 81-380; Coverage: 79%)
Gene names: SIAT8C, ST8SIA3
Sequence domains: Glycosyltransferase family 29 (sialyltransferase)
Structure domains: Glycosyl transferase family 29

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand 55T 2 x 55T
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-002
Spacegroup: P212121
Unit cell:
a: 72.84Å b: 96.64Å c: 124.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.235
Expression system: Spodoptera frugiperda

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