› 5dg1

X-ray diffraction
3.2Å resolution

Sugar binding protein - human galectin-2

Released:
DOI: 10.2210/pdb5dg1/pdb
PDB entry 5dg1 coloured by chain, front view.
PDB entry 5dg1 coloured by chain, side view.
PDB entry 5dg1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human galectin-2 interacts with carbohydrates and peptides non-classically: new insight from X-ray crystallography and hemagglutination.
Si Y, Feng S, Gao J, Wang Y, Zhang Z, Meng Y, Zhou Y, Tai G, Su J
Acta Biochim Biophys Sin (Shanghai) 48 939-947 (2016)
PMID: 27563008

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-529165 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-2 Chains: A, B, C, D, H, I
Molecule details ›
Chains: A, B, C, D, H, I
Length: 135 amino acids
Theoretical weight: 14.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05162 (Residues: 1-132; Coverage: 100%)
Gene name: LGALS2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Unit cell:
a: 38.5Å b: 106.78Å c: 182.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.3 0.297 0.321
Expression system: Escherichia coli

Quick links

Citations

3 review citations

A Brief History of Charcot-Leyden Crystal Protein/Galectin-10 Research.
Su J. (2018)
2 more