› 5dzx

X-ray diffraction
2.88Å resolution

Protocadherin beta 6 extracellular cadherin domains 1-4

Released:
DOI: 10.2210/pdb5dzx/pdb
PDB entry 5dzx coloured by chain, front view.
PDB entry 5dzx coloured by chain, side view.
PDB entry 5dzx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.
Goodman KM, Rubinstein R, Thu CA, Bahna F, Mannepalli S, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L
Neuron 90 709-23 (2016)
PMID: 27161523

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187605 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Protocadherin beta-6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 425 amino acids
Theoretical weight: 46.79 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q91XZ4 (Residues: 29-445; Coverage: 56%)
Gene name: Pcdhb6
Sequence domains:
Structure domains: Cadherins

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA, FUC
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand MAN 3 x MAN
Ligand CA 18 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 49.04Å b: 90.53Å c: 258.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.242 0.289
Expression system: Homo sapiens

Quick links

Citations

18 review citations

Regulation of neural circuit formation by protocadherins.
Peek et al. (2017)
17 more

6 mentions without citation

Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.
Goodman et al. (2016)
5 more