› 5erp

X-ray diffraction
2.7Å resolution

Crystal structure of human Desmocollin-2 ectodomain fragment EC2-5

Released:
DOI: 10.2210/pdb5erp/pdb
PDB entry 5erp coloured by chain, front view.
PDB entry 5erp coloured by chain, side view.
PDB entry 5erp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison OJ, Brasch J, Lasso G, Katsamba PS, Ahlsen G, Honig B, Shapiro L
Proc Natl Acad Sci U S A 113 7160-5 (2016)
PMID: 27298358

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Desmocollin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 451 amino acids
Theoretical weight: 50.33 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q02487 (Residues: 236-680; Coverage: 51%)
Gene names: CDHF2, DSC2, DSC3
Sequence domains: Cadherin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand MAN 8 x MAN
Ligand NAG 3 x NAG
Ligand CA 21 x CA
Ligand SO4 2 x SO4
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 146.216Å b: 94.166Å c: 126.307Å
α: 90° β: 93.66° γ: 90°
R-values:
R R work R free
0.225 0.224 0.262
Expression system: Homo sapiens

Quick links

Citations

34 review citations

Pemphigus.
Kasperkiewicz et al. (2017)
33 more

5 mentions without citation

Structural basis of adhesive binding by desmocollins and desmogleins.
Harrison et al. (2016)
4 more