Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
Gamma-secretase complex, APH1A-PSEN1 variant (preferred)
PDBe Complex ID:
PDB-CPX-156018 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Nicastrin
Molecule details ›
Chain: A
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Length: 709 amino acids
Theoretical weight: 78.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q92542 (Residues: 1-709; Coverage: 100%)
Sequence domains:
Presenilin-1
Molecule details ›
Chain: B
Length: 467 amino acids
Theoretical weight: 52.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Presenilin
Length: 467 amino acids
Theoretical weight: 52.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P49768 (Residues: 1-467; Coverage: 100%)
Sequence domains: Presenilin
Gamma-secretase subunit APH-1A
Gamma-secretase subunit PEN-2
