› 5g47

X-ray diffraction
2.45Å resolution

Structure of Gc glycoprotein from severe fever with thrombocytopenia syndrome virus in the trimeric postfusion conformation

Released:
DOI: 10.2210/pdb5g47/pdb
PDB entry 5g47 coloured by chain, front view.
PDB entry 5g47 coloured by chain, side view.
PDB entry 5g47 coloured by chain, top view.
Source organism: Severe fever with thrombocytopenia syndrome virus
Primary publication:
Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.
Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA
Proc Natl Acad Sci U S A 113 7154-9 (2016)
PMID: 27325770

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-579359 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycoprotein C Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 445 amino acids
Theoretical weight: 47.72 KDa
Source organism: Severe fever with thrombocytopenia syndrome virus
Expression system: Homo sapiens
UniProt:
  • Canonical: R4V2Q5 (Residues: 563-996; Coverage: 41%)
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I212121
Unit cell:
a: 147.36Å b: 152.27Å c: 160.38Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.232
Expression system: Homo sapiens

Quick links

Citations

13 review citations

Exploitation of glycosylation in enveloped virus pathobiology.
Watanabe et al. (2019)
12 more

13 mentions without citation

Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure.
Hulswit et al. (2021)
12 more