› 5gtz

X-ray diffraction
3Å resolution

Crystal structure of EGFR 696-1022 T790M in complex with JTS-1-39

Released:
DOI: 10.2210/pdb5gtz/pdb
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PDB entry 5gtz coloured by chain, front view.
PDB entry 5gtz coloured by chain, side view.
PDB entry 5gtz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yan XE, Yun CH

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 696-1022; Coverage: 28%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 81C 1 x 81C
Ligand EDO 4 x EDO
Ligand CL 5 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I23
Unit cell:
a: 146.177Å b: 146.177Å c: 146.177Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.23
Expression system: Spodoptera frugiperda

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