› 5h9s

X-ray diffraction
1.82Å resolution

Crystal Structure of Human Galectin-7 in Complex with TAZTDG

Released:
DOI: 10.2210/pdb5h9s/pdb
PDB entry 5h9s coloured by chain, front view.
PDB entry 5h9s coloured by chain, side view.
PDB entry 5h9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.
Hsieh TJ, Lin HY, Tu Z, Lin TC, Wu SC, Tseng YY, Liu FT, Hsu ST, Lin CH
OpenAccess logo Sci Rep 6 29457 (2016)
PMID: 27416897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155680 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Galectin-7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 155 amino acids
Theoretical weight: 17.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P47929 (Residues: 1-136; Coverage: 100%)
Gene names: LGALS7, LGALS7B, PIG1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand TGZ 1 x TGZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P212121
Unit cell:
a: 53.873Å b: 64.475Å c: 73.046Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.183 0.227
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

10 review citations

Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z.
Sciacchitano et al. (2018)
9 more

4 mentions without citation

Targeting Galectins With Glycomimetics.
Bertuzzi et al. (2020)
3 more