› 5hdt

X-ray diffraction
2.71Å resolution

Human cohesin regulator Pds5B bound to a Wapl peptide

Released:
DOI: 10.2210/pdb5hdt/pdb
PDB entry 5hdt coloured by chain, front view.
PDB entry 5hdt coloured by chain, side view.
PDB entry 5hdt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ouyang Z, Tomchick DR, Yu H

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-566406 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sister chromatid cohesion protein PDS5 homolog B Chains: A, B
Molecule details ›
Chains: A, B
Length: 1111 amino acids
Theoretical weight: 129.19 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NTI5 (Residues: 21-1120; Coverage: 76%)
Gene names: APRIN, AS3, KIAA0979, PDS5B
Sequence domains: Sister chromatid cohesion protein PDS5 protein
Wings apart-like protein homolog Chain: E
Molecule details ›
Chain: E
Length: 33 amino acids
Theoretical weight: 3.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7Z5K2 (Residues: 1-33; Coverage: 3%)
Gene names: FOE, KIAA0261, WAPAL, WAPL

Ligands and Environments

1 bound ligand:
Ligand IHP 2 x IHP
1 modified residue:
Ligand MSE 70 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 120.76Å b: 162.368Å c: 173.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.253
Expression systems:
  • Trichoplusia ni
  • Not provided

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