› 5hir

Solution NMR

SOLUTION STRUCTURE OF RECOMBINANT HIRUDIN AND THE LYS-47 (RIGHT ARROW) GLU MUTANT. A NUCLEAR MAGNETIC RESONANCE AND HYBRID DISTANCE GEOMETRY-DYNAMICAL SIMULATED ANNEALING STUDY

Released:
DOI: 10.2210/pdb5hir/pdb
PDB entry 5hir coloured by chain, front view.
PDB entry 5hir coloured by chain, side view.
PDB entry 5hir coloured by chain, top view.
Source organism: Hirudo medicinalis
Primary publication:
Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.
Folkers PJ, Clore GM, Driscoll PC, Dodt J, Köhler S, Gronenborn AM
Biochemistry 28 2601-17 (1989)
PMID: 2567183

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hirudin variant-1 Chain: A
Molecule details ›
Chain: A
Length: 65 amino acids
Theoretical weight: 6.97 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P01050 (Residues: 1-65; Coverage: 100%)
Sequence domains: Hirudin
Structure domains: Thrombin Inhibitor (Hirudin), subunit I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

14 review citations

Intrinsically disordered proteins in human diseases: introducing the D2 concept.
Uversky et al. (2008)
13 more

4 mentions without citation

The unfoldomics decade: an update on intrinsically disordered proteins.
Dunker et al. (2008)
3 more