5lsp

X-ray diffraction
2.6Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-209369 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Hepatocyte growth factor receptor Chains: A, P
Molecule details ›
Chains: A, P
Length: 231 amino acids
Theoretical weight: 25.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08581 (Residues: 519-743; Coverage: 17%)
Gene name: MET
Sequence domains:
107_A07 Fab heavy chain Chains: H, S
Molecule details ›
Chains: H, S
Length: 223 amino acids
Theoretical weight: 23.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
107_A07 Fab light chain Chains: L, T
Molecule details ›
Chains: L, T
Length: 216 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Hepatocyte growth factor receptor Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 14 amino acids
Theoretical weight: 1.63 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P08581 (Residues: 25-35; Coverage: 1%)
Gene name: MET

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Unit cell:
a: 71.88Å b: 82.279Å c: 267.304Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.215 0.256
Expression systems:
  • Cricetulus griseus
  • Homo sapiens