› 5nhr

X-ray diffraction
3.35Å resolution

CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, CUBIC CRYSTAL FORM

Released:
DOI: 10.2210/pdb5nhr/pdb
Model geometry
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PDB entry 5nhr coloured by chain, front view.
PDB entry 5nhr coloured by chain, side view.
PDB entry 5nhr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Morvan F, Rondeau JM, Zou C, Minetti G, Scheufler C, Scharenberg M, Jacobi C, Brebbia P, Ritter V, Toussaint G, Koelbing C, Leber X, Schilb A, Witte F, Lehmann S, Koch E, Geisse S, Glass DJ, Lach-Trifilieff E
OpenAccess logo Proc Natl Acad Sci U S A 114 12448-12453 (2017)
PMID: 29109273

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212014 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Bimagrumab Fv Light-Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 119 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
Bimagrumab Fv heavy-chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 121 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
Activin receptor type-2B Chains: C, D

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P23
Unit cell:
a: 187.826Å b: 187.826Å c: 187.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.229
Expression systems:
  • Escherichia coli str. K-12 substr. W3110
  • Escherichia coli K-12

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Citations

25 review citations

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake.
Merz et al. (2020)
24 more

1 mention without citation

Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy.
Morvan et al. (2017)

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