› 5nnt

X-ray diffraction
2.21Å resolution

The dimeric structure of LL-37 crystallized in DPC

Released:
DOI: 10.2210/pdb5nnt/pdb
PDB entry 5nnt coloured by chain, front view.
PDB entry 5nnt coloured by chain, side view.
PDB entry 5nnt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural remodeling and oligomerization of human cathelicidin on membranes suggest fibril-like structures as active species.
Sancho-Vaello E, François P, Bonetti EJ, Lilie H, Finger S, Gil-Ortiz F, Gil-Carton D, Zeth K
OpenAccess logo Sci Rep 7 15371 (2017)
PMID: 29133814

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156080 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antibacterial peptide LL-37 Chains: A, B
Molecule details ›
Chains: A, B
Length: 37 amino acids
Theoretical weight: 4.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P49913 (Residues: 134-170; Coverage: 26%)
Gene names: CAMP, CAP18, FALL39, HSD26
Sequence domains: LPS binding domain of CAP18 (C terminal)

Ligands and Environments

1 bound ligand:
Ligand DPV 2 x DPV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 35.209Å b: 43.703Å c: 54.398Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.263 0.287
Expression system: Not provided

Quick links

Citations

5 review citations

Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.
Monem et al. (2020)
4 more

8 mentions without citation

Structural Plasticity of LL-37 Indicates Elaborate Functional Adaptation Mechanisms to Bacterial Target Structures.
Zeth et al. (2021)
7 more