› 5o55

X-ray diffraction
1.45Å resolution

Crystal structure of the human BRPF1 bromodomain in complex with BZ047

Released:
DOI: 10.2210/pdb5o55/pdb
PDB entry 5o55 coloured by chain, front view.
PDB entry 5o55 coloured by chain, side view.
PDB entry 5o55 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Zhu J, Zhou C, Caflisch A
Eur J Med Chem 155 337-352 (2018)
PMID: 29902720

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-547548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peregrin Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 13.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55201 (Residues: 626-740; Coverage: 10%)
Gene names: BR140, BRPF1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand NO3 1 x NO3
Ligand 9L5 1 x 9L5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3221
Unit cell:
a: 60.695Å b: 60.695Å c: 63.147Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.177 0.201
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment.
Li et al. (2021)
3 more