› 5obn

Solution NMR

NMR solution structure of U11/U12 65K protein's C-terminal RRM domain (381-516)

Released:
DOI: 10.2210/pdb5obn/pdb
PDB entry 5obn coloured by chain, ensemble of 20 models, front view.
PDB entry 5obn coloured by chain, ensemble of 20 models, side view.
PDB entry 5obn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA.
Norppa AJ, Kauppala TM, Heikkinen HA, Verma B, Iwaï H, Frilander MJ
OpenAccess logo RNA 24 396-409 (2018)
PMID: 29255062

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-binding region-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 15.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96LT9 (Residues: 381-516; Coverage: 26%)
Gene names: KIAA1839, RBM40, RNP, RNPC3, SNRNP65
Sequence domains: RNA recognition motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Chemical shift assignment: 89%
Expression system: Escherichia coli

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Citations

1 review citation

The emerging role of minor intron splicing in neurological disorders.
Jutzi et al. (2018)
8 other articles

1 mention without citation

Machine learning and bioinformatics-based insights into the potential targets of saponins in Paris polyphylla smith against non-small cell lung cancer.
Wang et al. (2022)