› 5oc9

X-ray diffraction
3.2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-576372 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anoctamin-10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 667 amino acids
Theoretical weight: 77.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NW15 (Residues: 1-660; Coverage: 100%)
Gene names: ANO10, TMEM16K
Sequence domains: Calcium-activated chloride channel

Ligands and Environments

2 bound ligands:
Ligand CA 7 x CA
Ligand 79M 18 x 79M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 59.15Å b: 153.59Å c: 218.78Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.245
Expression system: Spodoptera frugiperda

Quick links

Citations

19 review citations

The diversity and breadth of cancer cell fatty acid metabolism.
Nagarajan et al. (2021)
18 more

7 mentions without citation

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Bushell et al. (2019)
6 more