› 5ouq

X-ray diffraction
5.11Å resolution

Structure of TgPLP1 MACPF domain

Released:
DOI: 10.2210/pdb5ouq/pdb
PDB entry 5ouq coloured by chain, front view.
PDB entry 5ouq coloured by chain, side view.
PDB entry 5ouq coloured by chain, top view.
Source organism: Toxoplasma gondii
Primary publication:
Structures of monomeric and oligomeric forms of the Toxoplasma gondii perforin-like protein 1.
Ni T, Williams SI, Rezelj S, Anderluh G, Harlos K, Stansfeld PJ, Gilbert RJC
OpenAccess logo Sci Adv 4 eaaq0762 (2018)
PMID: 29750191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-579614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Perforin-like protein 1 Chains: A, C, D, E, F, G
Molecule details ›
Chains: A, C, D, E, F, G
Length: 356 amino acids
Theoretical weight: 39.11 KDa
Source organism: Toxoplasma gondii
Expression system: Homo sapiens
UniProt:
  • Canonical: V5BCL0 (Residues: 473-816; Coverage: 30%)
Gene names: PLP1, TGVEG_204130
Sequence domains: MAC/Perforin domain

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 159.49Å b: 185.74Å c: 104.19Å
α: 90° β: 121.48° γ: 90°
R-values:
R R work R free
0.287 0.287 0.298
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Pathways of host cell exit by intracellular pathogens.
Flieger et al. (2018)
3 more