5vgz

Electron Microscopy
4.5Å resolution

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Released:
Source organism: Homo sapiens
Related structures: EMD-8672

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero heptadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126189 (preferred)
Entry contents:
17 distinct polypeptide molecules
Macromolecules (17 distinct):
26S proteasome regulatory subunit 7 Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35998 (Residues: 73-155; Coverage: 19%)
Gene names: MSS1, PSMC2
Sequence domains: 26S proteasome regulatory subunit 7, OB domain
26S proteasome regulatory subunit 4 Chain: B
Molecule details ›
Chain: B
Length: 73 amino acids
Theoretical weight: 7.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P62191 (Residues: 93-165; Coverage: 17%)
Gene name: PSMC1
Sequence domains: Proteasomal ATPase OB C-terminal domain
26S proteasome regulatory subunit 8 Chain: C
26S proteasome regulatory subunit 6B Chain: D
26S proteasome regulatory subunit 10B Chain: E
26S proteasome regulatory subunit 6A Chain: F
26S proteasome non-ATPase regulatory subunit 1 Chain: U
26S proteasome non-ATPase regulatory subunit 3 Chain: V
26S proteasome non-ATPase regulatory subunit 12 Chain: W
26S proteasome non-ATPase regulatory subunit 11 Chain: X
26S proteasome non-ATPase regulatory subunit 6 Chain: Y
26S proteasome non-ATPase regulatory subunit 7 Chain: Z
26S proteasome non-ATPase regulatory subunit 13 Chain: a
26S proteasome non-ATPase regulatory subunit 4 Chain: b
26S proteasome non-ATPase regulatory subunit 14 Chain: c
26S proteasome non-ATPase regulatory subunit 8 Chain: d
26S proteasome complex subunit SEM1 Chain: e

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.5Å
Relevant EMDB volumes: EMD-8672
Expression system: Homo sapiens