5vhf

Electron Microscopy
5.7Å resolution

Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle

Released:
Source organism: Homo sapiens
Related structures: EMD-8674

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero nonadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126187 (preferred)
Entry contents:
19 distinct polypeptide molecules
Macromolecules (19 distinct):
26S proteasome non-ATPase regulatory subunit 10 Chain: G
Molecule details ›
Chain: G
Length: 223 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75832 (Residues: 4-226; Coverage: 99%)
Gene name: PSMD10
Sequence domains: Ankyrin repeats (3 copies)
26S proteasome regulatory subunit 7 Chain: A
Molecule details ›
Chain: A
Length: 352 amino acids
Theoretical weight: 39.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35998 (Residues: 73-424; Coverage: 81%)
Gene names: MSS1, PSMC2
Sequence domains:
26S proteasome regulatory subunit 4 Chain: B
26S proteasome regulatory subunit 8 Chain: C
26S proteasome regulatory subunit 6B Chain: D
26S proteasome regulatory subunit 10B Chain: E
26S proteasome regulatory subunit 6A Chain: F
26S proteasome non-ATPase regulatory subunit 1 Chain: U
26S proteasome non-ATPase regulatory subunit 3 Chain: V
26S proteasome non-ATPase regulatory subunit 12 Chain: W
26S proteasome non-ATPase regulatory subunit 11 Chain: X
26S proteasome non-ATPase regulatory subunit 6 Chain: Y
26S proteasome non-ATPase regulatory subunit 7 Chain: Z
26S proteasome non-ATPase regulatory subunit 13 Chain: a
26S proteasome non-ATPase regulatory subunit 4 Chain: b
26S proteasome non-ATPase regulatory subunit 14 Chain: c
26S proteasome non-ATPase regulatory subunit 8 Chain: d
26S proteasome complex subunit SEM1 Chain: e
26S proteasome non-ATPase regulatory subunit 2 Chain: f

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 5.7Å
Relevant EMDB volumes: EMD-8674
Expression system: Homo sapiens