5w7x

X-ray diffraction
2Å resolution

Crystal Structure of FHA domain of human APLF in complex with XRCC1 bisphospho peptide

Released:

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-148466 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aprataxin and PNK-like factor Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 108 amino acids
Theoretical weight: 11.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IW19 (Residues: 1-105; Coverage: 21%)
Gene names: APLF, C2orf13, PALF, XIP1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
DNA repair protein XRCC1 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 9 amino acids
Theoretical weight: 1.11 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P18887 (Residues: 514-522; Coverage: 1%)
Gene name: XRCC1

Ligands and Environments

No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 59.119Å b: 36.799Å c: 98.284Å
α: 90° β: 90.86° γ: 90°
R-values:
R R work R free
0.194 0.192 0.229
Expression systems:
  • Escherichia coli
  • Not provided