› 5wp1

X-ray diffraction
1.4Å resolution

Complex of ERK2 with 5,7-dihydroxychromone

Released:
DOI: 10.2210/pdb5wp1/pdb
PDB entry 5wp1 coloured by chain, front view.
PDB entry 5wp1 coloured by chain, side view.
PDB entry 5wp1 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kurinov I, Malakhova M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 357 amino acids
Theoretical weight: 41.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28482 (Residues: 4-360; Coverage: 99%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand B7S 1 x B7S
Ligand SO4 1 x SO4
Ligand BEZ 1 x BEZ
1 modified residue:
Ligand CME 3 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 48.685Å b: 69.07Å c: 59.845Å
α: 90° β: 108.14° γ: 90°
R-values:
R R work R free
0.142 0.141 0.18
Expression system: Escherichia coli BL21(DE3)

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