› 5xi3

X-ray diffraction
1.67Å resolution

BRD4 bound with compound Bdi3

Released:
DOI: 10.2210/pdb5xi3/pdb
PDB entry 5xi3 coloured by chain, front view.
PDB entry 5xi3 coloured by chain, side view.
PDB entry 5xi3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Xiong B, Cao D, Li Y

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 14.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-166; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand 8F6 1 x 8F6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U1
Spacegroup: P212121
Unit cell:
a: 32.478Å b: 47.581Å c: 78.714Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.218
Expression system: Escherichia coli

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