› 5xw6

X-ray diffraction
3.1Å resolution

Crystal structure of the chicken ATP-gated P2X7 receptor channel in the presence of competitive antagonist TNP-ATP at 3.1 Angstroms

Released:
DOI: 10.2210/pdb5xw6/pdb
PDB entry 5xw6 coloured by chain, front view.
PDB entry 5xw6 coloured by chain, side view.
PDB entry 5xw6 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.
Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O
OpenAccess logo Nat Commun 8 876 (2017)
PMID: 29026074

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-237300 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2X purinoceptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 327 amino acids
Theoretical weight: 37.34 KDa
Source organism: Gallus gallus
Expression system: Homo sapiens
Structure domains: atp-gated p2x4 ion channel domain

Ligands and Environments

2 bound ligands:
Ligand NAG 3 x NAG
Ligand 128 3 x 128
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 113.038Å b: 113.038Å c: 333.472Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.22 0.248
Expression system: Homo sapiens

Quick links

Citations

11 review citations

The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.
Burnstock et al. (2018)
10 more

10 mentions without citation

P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming?
Young et al. (2018)
9 more