› 5zsj

X-ray diffraction
2.4Å resolution

Crystal structure of monkey TLR7 in complex with GS9620

Released:
DOI: 10.2210/pdb5zsj/pdb
PDB entry 5zsj coloured by chain, front view.
PDB entry 5zsj coloured by chain, side view.
PDB entry 5zsj coloured by chain, top view.
Source organism: Macaca mulatta
Primary publication:
Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T
Cell Rep 25 3371-3381.e5 (2018)
PMID: 30566863

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
TIR domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 823 amino acids
Theoretical weight: 94.75 KDa
Source organism: Macaca mulatta
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: B3Y653 (Residues: 27-839; Coverage: 78%)
Gene name: TLR7
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand 9JR 2 x 9JR
Ligand NAG 12 x NAG
Ligand SO4 11 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P212121
Unit cell:
a: 99.073Å b: 138.637Å c: 149.331Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.236
Expression system: Drosophila melanogaster

Quick links

Citations

27 review citations

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation.
Gu et al. (2021)
26 more