› 5agx

X-ray diffraction
2.24Å resolution

Bcl-2 alpha beta-1 LINEAR complex

Released:
DOI: 10.2210/pdb5agx/pdb
Model geometry
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PDB entry 5agx coloured by chain, front view.
PDB entry 5agx coloured by chain, side view.
PDB entry 5agx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.
Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH, Fairlie WD
J Am Chem Soc 137 11365-75 (2015)
PMID: 26317395

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128960 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 166 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:
Apoptosis regulator Bcl-2; Bcl-2-like protein 1 Chain: B
Molecule details ›
Chain: B
Length: 166 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-34, 66-207; Coverage: 63%)
  • Canonical: Q07817 (Residues: 29-44; Coverage: 7%)
Gene names: BCL2, BCL2L, BCL2L1, BCLX
Sequence domains:
Bcl-2-like protein 11 Chains: C, D

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P43212
Unit cell:
a: 86.054Å b: 86.054Å c: 108.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.245
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

12 review citations

Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics.
Ding et al. (2020)
11 more

2 mentions without citation

α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.
Checco et al. (2015)
1 more

PDB-REDO

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