› 5akt

X-ray diffraction
1.35Å resolution

Transthyretin binding heterogeneity and anti-amyloidogenic activity of natural polyphenols and their metabolites: resveratrol-4'-O- glucuronide

Released:
DOI: 10.2210/pdb5akt/pdb
PDB entry 5akt coloured by chain, front view.
PDB entry 5akt coloured by chain, side view.
PDB entry 5akt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and Their Metabolites.
Florio P, Folli C, Cianci M, Del Rio D, Zanotti G, Berni R
J Biol Chem 290 29769-80 (2015)
PMID: 26468275

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand R4G 2 x R4G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P21212
Unit cell:
a: 42.741Å b: 85.496Å c: 63.672Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.17 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy?
Weiskirchen et al. (2016)
9 more

2 mentions without citation

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design.
Ciccone et al. (2020)
1 more