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Crystal structure of human SAMHD1 (amino acid residues 115-583) bound to ddGTP

X-ray diffraction
2.545Å resolution
PDB entry 5ao1 coloured by chain, front view.
PDB entry 5ao1 coloured by chain, side view.
PDB entry 5ao1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
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Multimeric state: homo tetramer
Accessible surface area: 67084.96 Å2
Buried surface area: 17828.32 Å2
Dissociation area: 1,167.94 Å2
Dissociation energy (ΔGdiss): 1.32 kcal/mol
Dissociation entropy (TΔSdiss): 15.34 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195223

Macromolecules

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Chains: A, B, C, D
Length: 491 amino acids
Theoretical weight: 56.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 115-583; Coverage: 75%)
Gene names: MOP5, SAMHD1
Pfam: HD domain
InterPro:
CATH: Hypothetical protein af1432
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 5ao1, assembly 1, front view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 5ao1, assembly 1, side view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 5ao1, assembly 1, top view.
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