Structure analysis

Crystal structure of human SAMHD1 (amino acid residues 115-583) bound to ddGTP

X-ray diffraction
2.545Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 67084.96 Å2
Buried surface area: 17828.32 Å2
Dissociation area: 1,167.94 Å2
Dissociation energy (ΔGdiss): 1.32 kcal/mol
Dissociation entropy (TΔSdiss): 15.34 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195223

Macromolecules

Chains: A, B, C, D
Length: 491 amino acids
Theoretical weight: 56.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 115-583; Coverage: 75%)
Gene names: MOP5, SAMHD1
Pfam: HD domain
InterPro:
CATH: Hypothetical protein af1432

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