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Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Source organism: Homo sapiens
Biochemical function: protein-folding chaperone binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.4.10: Non-chaperonin molecular chaperone ATPase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (polypeptide-polymerizing)
Alternative Name(s):
  • Molecular chaperone Hsc70 ATPase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02179
Domain description: BAG domain
Occurring in:
  1. BAG family molecular chaperone regulator 1
The deposited structure of PDB entry 5aqg contains 3 copies of Pfam domain PF02179 (BAG domain) in BAG family molecular chaperone regulator 1. Showing 1 copy in chain D.

PF00012
Domain description: Hsp70 protein
Occurring in:
  1. Heat shock cognate 71 kDa protein
The deposited structure of PDB entry 5aqg contains 3 copies of Pfam domain PF00012 (Hsp70 protein) in Heat shock cognate 71 kDa protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018181
Domain description: Heat shock protein 70, conserved site
Occurring in:
  1. Heat shock cognate 71 kDa protein
IPR003103
Domain description: BAG domain
Occurring in:
  1. BAG family molecular chaperone regulator 1
IPR036533
Domain description: BAG domain superfamily
Occurring in:
  1. BAG family molecular chaperone regulator 1
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Heat shock cognate 71 kDa protein
IPR039773
Domain description: Molecular chaperone regulator BAG
Occurring in:
  1. BAG family molecular chaperone regulator 1
IPR013126
Domain description: Heat shock protein 70 family
Occurring in:
  1. Heat shock cognate 71 kDa protein

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Heat shock cognate 71 kDa protein
The deposited structure of PDB entry 5aqg contains 6 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Heat shock cognate 71 kDa protein. Showing 2 copies in chain A.
1.20.58.120
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology: BAG domain
Occurring in:
  1. BAG family molecular chaperone regulator 1
The deposited structure of PDB entry 5aqg contains 3 copies of CATH domain 1.20.58.120 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in BAG family molecular chaperone regulator 1. Showing 1 copy in chain D.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Heat shock cognate 71 kDa protein
The deposited structure of PDB entry 5aqg contains 3 copies of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Heat shock cognate 71 kDa protein. Showing 1 copy in chain A.
3.30.30.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Defensin A-like
Homology: Defensin A-like
Occurring in:
  1. Heat shock cognate 71 kDa protein
The deposited structure of PDB entry 5aqg contains 3 copies of CATH domain 3.30.30.30 (Defensin A-like) in Heat shock cognate 71 kDa protein. Showing 1 copy in chain A.

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