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Kinetics by X-ray crystallography: Tl+-substitution of bound K+ in the E2.MgF42-.2K+ crystal after 55 min

Source organism: Squalus acanthias
Biochemical function: ion channel regulator activity
Biological process: potassium ion import across plasma membrane
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF02038
Domain description: ATP1G1/PLM/MAT8 family
Occurring in:
  1. FXYD domain-containing ion transport regulator
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF02038 (ATP1G1/PLM/MAT8 family) in FXYD domain-containing ion transport regulator. Showing 1 copy in chain C [auth G].

PF00287
Domain description: Sodium / potassium ATPase beta chain
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit beta
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF00287 (Sodium / potassium ATPase beta chain) in Sodium/potassium-transporting ATPase subunit beta. Showing 1 copy in chain B.

PF00689
Domain description: Cation transporting ATPase, C-terminus
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF00689 (Cation transporting ATPase, C-terminus) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00702
Domain description: haloacid dehalogenase-like hydrolase
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF00702 (haloacid dehalogenase-like hydrolase) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF13246
Domain description: Cation transport ATPase (P-type)
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF13246 (Cation transport ATPase (P-type)) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00122
Domain description: E1-E2 ATPase
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF00122 (E1-E2 ATPase) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

PF00690
Domain description: Cation transporter/ATPase, N-terminus
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of Pfam domain PF00690 (Cation transporter/ATPase, N-terminus) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000402
Domain description: Sodium/potassium-transporting ATPase subunit beta
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit beta
IPR023299
Domain description: P-type ATPase, cytoplasmic domain N
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR001757
Domain description: P-type ATPase
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR004014
Domain description: Cation-transporting P-type ATPase, N-terminal
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR005775
Domain description: P-type ATPase subfamily IIC, subunit alpha
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR047297
Domain description: Ion-transport regulator, FXYD motif
Occurring in:
  1. FXYD domain-containing ion transport regulator
IPR000272
Domain description: Ion-transport regulator, FXYD family
Occurring in:
  1. FXYD domain-containing ion transport regulator
IPR038702
Domain description: Sodium/potassium-transporting ATPase subunit beta superfamily
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit beta
IPR006068
Domain description: Cation-transporting P-type ATPase, C-terminal
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR018303
Domain description: P-type ATPase, phosphorylation site
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR044492
Domain description: P-type ATPase, haloacid dehalogenase domain
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR008250
Domain description: P-type ATPase, A domain superfamily
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
IPR023298
Domain description: P-type ATPase, transmembrane domain superfamily
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha

Structure domains

CATH CATH domains
1.20.1110.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Calcium-transporting ATPase, transmembrane domain
Homology: Calcium-transporting ATPase, transmembrane domain
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 1.20.1110.10 (Calcium-transporting ATPase, transmembrane domain) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.
2.70.150.10
Class: Mainly Beta
Architecture: Distorted Sandwich
Topology: Calcium-transporting ATPase, cytoplasmic transduction domain A
Homology: Calcium-transporting ATPase, cytoplasmic transduction domain A
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 2.70.150.10 (Calcium-transporting ATPase, cytoplasmic transduction domain A) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.
2.60.40.1660
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Na, k-atpase alpha subunit.
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit beta
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 2.60.40.1660 (Immunoglobulin-like) in Sodium/potassium-transporting ATPase subunit beta. Showing 1 copy in chain B.
1.20.5.170
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit beta
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 1.20.5.170 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Sodium/potassium-transporting ATPase subunit beta. Showing 1 copy in chain B.
3.40.1110.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Calcium-transporting ATPase, cytoplasmic domain N
Homology: Calcium-transporting ATPase, cytoplasmic domain N
Occurring in:
  1. Sodium/potassium-transporting ATPase subunit alpha
The deposited structure of PDB entry 5avz contains 1 copy of CATH domain 3.40.1110.10 (Calcium-transporting ATPase, cytoplasmic domain N) in Sodium/potassium-transporting ATPase subunit alpha. Showing 1 copy in chain A.

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