› 5b7b

X-ray diffraction
3Å resolution

Crystal structure of Nucleoprotein-nucleozin complex

Released:
DOI: 10.2210/pdb5b7b/pdb
PDB entry 5b7b coloured by chain, front view.
PDB entry 5b7b coloured by chain, side view.
PDB entry 5b7b coloured by chain, top view.
Source organism: Influenza A virus (A/Wilson-Smith/1933(H1N1))
Primary publication:
Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites.
Pang B, Cheung NN, Zhang W, Dai J, Kao RY, Zhang H, Hao Q
OpenAccess logo Sci Rep 6 29684 (2016)
PMID: 27404920

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 498 amino acids
Theoretical weight: 56.45 KDa
Source organism: Influenza A virus (A/Wilson-Smith/1933(H1N1))
Expression system: Escherichia coli
UniProt:
  • Canonical: P15682 (Residues: 1-498; Coverage: 100%)
Gene name: NP
Sequence domains: Influenza virus nucleoprotein

Ligands and Environments

1 bound ligand:
Ligand NUZ 2 x NUZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 129.021Å b: 121.557Å c: 195.541Å
α: 90° β: 89.79° γ: 90°
R-values:
R R work R free
0.203 0.2 0.262
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Targeting protein-protein interaction interfaces in COVID-19 drug discovery.
Chang et al. (2021)
2 more

2 mentions without citation

Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites.
Pang et al. (2016)
1 more