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Bianthranilate-like inhibitor with 4-atom "line" and phosphonate "hook" fishing for hydrogen bond donors in Mycobacterium tuberculosis anthranilate phosphoribosyltransferase (AnPRT; trpD)

Source organism: Mycobacterium tuberculosis H37Ra
Biochemical function: metal ion binding
Biological process: tryptophan biosynthetic process
Cellular component: cytosol

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EC 2.4.2.18: Anthranilate phosphoribosyltransferase

Reaction catalysed:
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate
Systematic name:
N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase
Alternative Name(s):
  • Anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase
  • Anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase
  • Anthranilate-PP-ribose-P phosphoribosyltransferase
  • PRT
  • Phosphoribosyl-anthranilate diphosphorylase
  • Phosphoribosyl-anthranilate pyrophosphorylase
  • Phosphoribosylanthranilate pyrophosphorylase
  • Phosphoribosylanthranilate transferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00591
Domain description: Glycosyl transferase family, a/b domain
Occurring in:
  1. Anthranilate phosphoribosyltransferase
The deposited structure of PDB entry 5bo2 contains 2 copies of Pfam domain PF00591 (Glycosyl transferase family, a/b domain) in Anthranilate phosphoribosyltransferase. Showing 1 copy in chain B.

PF02885
Domain description: Glycosyl transferase family, helical bundle domain
Occurring in:
  1. Anthranilate phosphoribosyltransferase
The deposited structure of PDB entry 5bo2 contains 2 copies of Pfam domain PF02885 (Glycosyl transferase family, helical bundle domain) in Anthranilate phosphoribosyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR005940
Domain description: Anthranilate phosphoribosyl transferase
Occurring in:
  1. Anthranilate phosphoribosyltransferase
IPR035902
Domain description: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily
Occurring in:
  1. Anthranilate phosphoribosyltransferase
IPR000312
Domain description: Glycosyl transferase, family 3
Occurring in:
  1. Anthranilate phosphoribosyltransferase
IPR017459
Domain description: Glycosyl transferase family 3, N-terminal domain
Occurring in:
  1. Anthranilate phosphoribosyltransferase
IPR036320
Domain description: Glycosyl transferase family 3, N-terminal domain superfamily
Occurring in:
  1. Anthranilate phosphoribosyltransferase

Structure domains

CATH CATH domains
3.40.1030.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
Homology: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Occurring in:
  1. Anthranilate phosphoribosyltransferase
The deposited structure of PDB entry 5bo2 contains 2 copies of CATH domain 3.40.1030.10 (Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2) in Anthranilate phosphoribosyltransferase. Showing 1 copy in chain B.
1.20.970.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homology: Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Occurring in:
  1. Anthranilate phosphoribosyltransferase
The deposited structure of PDB entry 5bo2 contains 2 copies of CATH domain 1.20.970.10 (Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3) in Anthranilate phosphoribosyltransferase. Showing 1 copy in chain B.

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