› 5bup

X-ray diffraction
2.25Å resolution

Crystal structure of the ZP-C domain of mouse ZP2

Released:
DOI: 10.2210/pdb5bup/pdb
PDB entry 5bup coloured by chain, front view.
PDB entry 5bup coloured by chain, side view.
PDB entry 5bup coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
A structured interdomain linker directs self-polymerization of human uromodulin.
Bokhove M, Nishimura K, Brunati M, Han L, de Sanctis D, Rampoldi L, Jovine L
Proc Natl Acad Sci U S A 113 1552-7 (2016)
PMID: 26811476

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148882 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zona pellucida sperm-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.83 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P20239 (Residues: 463-664; Coverage: 30%)
Gene names: Zp-2, Zp2, Zpa
Sequence domains: Zona pellucida-like domain
Structure domains: Zona pellucida, ZP-C domain

Ligands and Environments

1 bound ligand:
Ligand ACT 3 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P61
Unit cell:
a: 105.21Å b: 105.21Å c: 40.55Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.201 0.228
Expression system: Homo sapiens

Quick links

Citations

17 review citations

Isolation of Extracellular Vesicles: General Methodologies and Latest Trends.
Konoshenko et al. (2018)
16 more

4 mentions without citation

Mammalian egg coat modifications and the block to polyspermy.
Fahrenkamp et al. (2020)
3 more