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1E6 TCR in complex with HLA-A02 carrying MVW peptide

Source organism: Homo sapiens
Biochemical function: peptide antigen binding
Biological process: immune system process
Cellular component: membrane

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor beta constant 2; T cell receptor beta variable 12-4
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Beta-2-microglobulin. Showing 1 copy in chain B.
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF07654 (Immunoglobulin C1-set domain) in T cell receptor beta constant 2. Showing 1 copy in chain E.

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  2. T cell receptor beta constant 2; T cell receptor beta variable 12-4
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in T cell receptor alpha chain constant. Showing 1 copy in chain D.
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF07686 (Immunoglobulin V-set domain) in T cell receptor beta constant 2. Showing 1 copy in chain E.

PF09291
Domain description: Domain of unknown function (DUF1968)
Occurring in:
  1. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF09291 (Domain of unknown function (DUF1968)) in T cell receptor alpha chain constant. Showing 1 copy in chain D.

PF00129
Domain description: Class I Histocompatibility antigen, domains alpha 1 and 2
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5c0a contains 2 copies of Pfam domain PF00129 (Class I Histocompatibility antigen, domains alpha 1 and 2) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  4. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  4. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  4. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  2. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR001039
Domain description: MHC class I alpha chain, alpha1 alpha2 domains
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  2. T cell receptor beta constant 2; T cell receptor beta variable 12-4
IPR015707
Domain description: Beta-2-Microglobulin
Occurring in:
  1. Beta-2-microglobulin
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
IPR011161
Domain description: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
  2. Beta-2-microglobulin
  3. T cell receptor alpha chain constant; T cell receptor alpha variable 12-3
  4. T cell receptor beta constant 2; T cell receptor beta variable 12-4
The deposited structure of PDB entry 5c0a contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 5c0a contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Beta-2-microglobulin. Showing 1 copy in chain B.
The deposited structure of PDB entry 5c0a contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T cell receptor alpha chain constant. Showing 2 copies in chain D.
The deposited structure of PDB entry 5c0a contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T cell receptor beta constant 2. Showing 2 copies in chain E.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. HLA class I histocompatibility antigen, A alpha chain
The deposited structure of PDB entry 5c0a contains 2 copies of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in HLA class I histocompatibility antigen, A alpha chain. Showing 1 copy in chain A.

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