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Crystal structure of SYK in complex with compound 1

X-ray diffraction
1.95Å resolution
PDB entry 5c26 coloured by chain, front view.
PDB entry 5c26 coloured by chain, side view.
PDB entry 5c26 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase SYK and peptide
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Multimeric state: hetero dimer
Accessible surface area: 14139.29 Å2
Buried surface area: 822.12 Å2
Dissociation area: 411.06 Å2
Dissociation energy (ΔGdiss): 1.38 kcal/mol
Dissociation entropy (TΔSdiss): 6.66 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155059

Macromolecules

Tyrosine-protein kinase SYK
Chain: A
Length: 299 amino acids
Theoretical weight: 35.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43405 (Residues: 343-635; Coverage: 46%)
Gene name: SYK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase SYK in PDB entry 5c26, assembly 1, front view.
Tyrosine-protein kinase SYK in PDB entry 5c26, assembly 1, side view.
Tyrosine-protein kinase SYK in PDB entry 5c26, assembly 1, top view.
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GLU-VAL-PTR-GLU-SER-PRO
Chain: B
Length: 6 amino acids
Theoretical weight: 803 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
GLU-VAL-PTR-GLU-SER-PRO in PDB entry 5c26, assembly 1, front view.
GLU-VAL-PTR-GLU-SER-PRO in PDB entry 5c26, assembly 1, side view.
GLU-VAL-PTR-GLU-SER-PRO in PDB entry 5c26, assembly 1, top view.
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