› 5c2z

X-ray diffraction
1.96Å resolution

Molecular insights into the specificity of exfoliative toxins from Staphylococcus aureus

Released:
DOI: 10.2210/pdb5c2z/pdb
PDB entry 5c2z coloured by chain, front view.
PDB entry 5c2z coloured by chain, side view.
PDB entry 5c2z coloured by chain, top view.
Source organism: Staphylococcus aureus
Primary publication:
Crystal structure of Staphylococcus aureus exfoliative toxin D-like protein: Structural basis for the high specificity of exfoliative toxins.
Mariutti RB, Souza TA, Ullah A, Caruso IP, de Moraes FR, Zanphorlin LM, Tartaglia NR, Seyffert N, Azevedo VA, Le Loir Y, Murakami MT, Arni RK
Biochem Biophys Res Commun 467 171-7 (2015)
PMID: 26299923

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125783 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease Chains: A, B
Molecule details ›
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.15 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Canonical: L0RUV7 (Residues: 33-280; Coverage: 89%)
Gene name: etD2
Sequence domains: Trypsin-like peptidase domain
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P21
Unit cell:
a: 49.412Å b: 93.141Å c: 50.478Å
α: 90° β: 91.23° γ: 90°
R-values:
R R work R free
0.181 0.177 0.252
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Staphylococcus schweitzeri-An Emerging One Health Pathogen?
Akoua-Koffi et al. (2022)
4 other articles

3 mentions without citation

Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity.
Imanishi et al. (2019)
2 more