› 5c7z

X-ray diffraction
2.77Å resolution

AP2 Mu2 adaptin C-terminal domain complexed with integrin alpha-4 peptide

Released:
DOI: 10.2210/pdb5c7z/pdb
PDB entry 5c7z coloured by chain, front view.
PDB entry 5c7z coloured by chain, side view.
PDB entry 5c7z coloured by chain, top view.
Source organisms:
Entry authors: Owen DJ, Evans PR, Wilson TA

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146673 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
AP-2 complex subunit mu Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 32.99 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P84092 (Residues: 159-236, 237-435; Coverage: 64%)
Gene name: Ap2m1
Sequence domains: Adaptor complexes medium subunit family
Structure domains: Mu homology domain, subdomain B
Integrin alpha-4 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13612 (Residues: 1008-1015; Coverage: 1%)
Gene names: CD49D, ITGA4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E DW
Spacegroup: P64
Unit cell:
a: 125.65Å b: 125.65Å c: 74.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.174 0.224
Expression systems:
  • Escherichia coli
  • Not provided

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