› 5cbw

X-ray diffraction
1.8Å resolution

Human Cyclophilin D Complexed with Inhibitor.

Released:
DOI: 10.2210/pdb5cbw/pdb
PDB entry 5cbw coloured by chain, front view.
PDB entry 5cbw coloured by chain, side view.
PDB entry 5cbw coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gibson RP, Shore E, Kershaw N, Awais M, Javed A, Latawiec D, Pandalaneni S, Wen L, Berry N, O'Neill P, Sutton R, Lian LY

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-542157 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase F, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 17.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P30405 (Residues: 44-207; Coverage: 79%)
Gene names: CYP3, PPIF
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

5 bound ligands:
Ligand K 2 x K
Ligand FMT 1 x FMT
Ligand PG4 1 x PG4
Ligand PGE 1 x PGE
Ligand 4ZO 1 x 4ZO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P43212
Unit cell:
a: 57.265Å b: 57.265Å c: 114.502Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.208
Expression system: Escherichia coli BL21(DE3)

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