5cez

X-ray diffraction
3.03Å resolution

Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with an early putative precursor of the PGT121 family at 3.0 Angstrom

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-230349 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (12 distinct):
Envelope glycoprotein gp160 Chain: G
Molecule details ›
Chain: G
Length: 480 amino acids
Theoretical weight: 53.95 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 31-505, 508-508; Coverage: 55%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Transmembrane protein gp41 Chain: B
Molecule details ›
Chain: B
Length: 153 amino acids
Theoretical weight: 17.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: Q2N0S6 (Residues: 509-661; Coverage: 18%)
Gene name: env
Sequence domains: Retroviral envelope protein
3H+109L Fab Light Chain Chain: L
3H+109L Fab Heavy Chain Chain: H
35022 Fab Heavy Chain Chain: D
35022 Fab Light Chain Chain: E

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P63
Unit cell:
a: 127.978Å b: 127.978Å c: 316.124Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.233 0.266
Expression system: Homo sapiens