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Isobutyryl-CoA mutase fused with bound adenosylcobalamin, GDP, Mg (holo-IcmF/GDP), and substrate isobutyryl-coenzyme A

Source organism: Cupriavidus metallidurans CH34
Biochemical function: membrane scission GTPase motor activity
Biological process: acyl-CoA metabolic process
Cellular component: not assigned

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EC 5.4.99.13: Isobutyryl-CoA mutase

Reaction catalysed:
2-methylpropanoyl-CoA = butanoyl-CoA
Systematic name:
2-methylpropanoyl-CoA CoA-carbonylmutase
Alternative Name(s):
  • Butyryl-CoA:isobutyryl-CoA mutase
  • Isobutyryl coenzyme A mutase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01642
Domain description: Methylmalonyl-CoA mutase
Occurring in:
  1. Fused isobutyryl-CoA mutase
The deposited structure of PDB entry 5cjt contains 2 copies of Pfam domain PF01642 (Methylmalonyl-CoA mutase) in Fused isobutyryl-CoA mutase. Showing 1 copy in chain A.

PF03308
Domain description: Methylmalonyl Co-A mutase-associated GTPase MeaB
Occurring in:
  1. Fused isobutyryl-CoA mutase
The deposited structure of PDB entry 5cjt contains 2 copies of Pfam domain PF03308 (Methylmalonyl Co-A mutase-associated GTPase MeaB) in Fused isobutyryl-CoA mutase. Showing 1 copy in chain A.

PF02310
Domain description: B12 binding domain
Occurring in:
  1. Fused isobutyryl-CoA mutase
The deposited structure of PDB entry 5cjt contains 2 copies of Pfam domain PF02310 (B12 binding domain) in Fused isobutyryl-CoA mutase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR006158
Domain description: Cobalamin (vitamin B12)-binding domain
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR006098
Domain description: Methylmalonyl-CoA mutase, alpha chain, catalytic
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR006099
Domain description: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR016176
Domain description: Cobalamin (vitamin B12)-dependent enzyme, catalytic
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR033669
Domain description: Fused isobutyryl-CoA mutase
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR006159
Domain description: Methylmalonyl-CoA mutase, C-terminal
Occurring in:
  1. Fused isobutyryl-CoA mutase
IPR036724
Domain description: Cobalamin-binding domain superfamily
Occurring in:
  1. Fused isobutyryl-CoA mutase

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