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Complex structure of Norrin with human Frizzled 4

Source organisms:
Biochemical function: protein homodimerization activity
Biological process: establishment of blood-retinal barrier
Cellular component: collagen-containing extracellular matrix

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01392
Domain description: Fz domain
Occurring in:
  1. Frizzled-4
The deposited structure of PDB entry 5cl1 contains 2 copies of Pfam domain PF01392 (Fz domain) in Frizzled-4. Showing 1 copy in chain D.

PF00007
Domain description: Cystine-knot domain
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
The deposited structure of PDB entry 5cl1 contains 2 copies of Pfam domain PF00007 (Cystine-knot domain) in Maltose/maltodextrin-binding periplasmic protein. Showing 1 copy in chain A.

PF01547
Domain description: Bacterial extracellular solute-binding protein
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
The deposited structure of PDB entry 5cl1 contains 2 copies of Pfam domain PF01547 (Bacterial extracellular solute-binding protein) in Maltose/maltodextrin-binding periplasmic protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006060
Domain description: Maltose/Cyclodextrin ABC transporter, substrate-binding protein
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
IPR020067
Domain description: Frizzled domain
Occurring in:
  1. Frizzled-4
IPR006207
Domain description: Cystine knot, C-terminal
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
IPR036790
Domain description: Frizzled cysteine-rich domain superfamily
Occurring in:
  1. Frizzled-4
IPR041765
Domain description: Frizzled 4, cysteine-rich domain
Occurring in:
  1. Frizzled-4
IPR015526
Domain description: Frizzled/secreted frizzled-related protein
Occurring in:
  1. Frizzled-4
IPR006208
Domain description: Glycoprotein hormone subunit beta
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
IPR029034
Domain description: Cystine-knot cytokine
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
IPR006061
Domain description: Solute-binding family 1, conserved site
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin
IPR006059
Domain description: Bacterial-type extracellular solute-binding protein
Occurring in:
  1. Maltose/maltodextrin-binding periplasmic protein; Norrin

Structure domain

CATH CATH domain
1.10.2000.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Frizzled cysteine-rich domain
Homology: Frizzled cysteine-rich domain
Occurring in:
  1. Frizzled-4
The deposited structure of PDB entry 5cl1 contains 2 copies of CATH domain 1.10.2000.10 (Frizzled cysteine-rich domain) in Frizzled-4. Showing 1 copy in chain D.

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