› 5cmc

X-ray diffraction
1.28Å resolution

Mnemiopsis leidyi ML032222a iGluR LBD E423S mutant glycine complex

Released:
DOI: 10.2210/pdb5cmc/pdb
PDB entry 5cmc coloured by chain, front view.
PDB entry 5cmc coloured by chain, side view.
PDB entry 5cmc coloured by chain, top view.
Source organism: Mnemiopsis leidyi
Primary publication:
Molecular lock regulates binding of glycine to a primitive NMDA receptor.
Yu A, Alberstein R, Thomas A, Zimmet A, Grey R, Mayer ML, Lau AY
Proc Natl Acad Sci U S A 113 E6786-E6795 (2016)
PMID: 27791085

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ML032222a iGluR Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 28.92 KDa
Source organism: Mnemiopsis leidyi
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0R4I973 (Residues: 1-256; Coverage: 100%)
Gene name: ML032222a
Sequence domains: Ligated ion channel L-glutamate- and glycine-binding site
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand GLY 2 x GLY
Ligand MG 1 x MG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 45.899Å b: 123.138Å c: 54.507Å
α: 90° β: 111.72° γ: 90°
R-values:
R R work R free
0.136 0.134 0.157
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.
Moroz et al. (2021)
5 more

6 mentions without citation

Molecular lock regulates binding of glycine to a primitive NMDA receptor.
Yu et al. (2016)
5 more