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Artificial HIV fusion inhibitor AP2 fused to the C-terminus of gp41 NHR

X-ray diffraction
1.901Å resolution
PDB entry 5cn0 coloured by chain, front view.
PDB entry 5cn0 coloured by chain, side view.
PDB entry 5cn0 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Transmembrane protein gp41
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Multimeric state: homo trimer
Accessible surface area: 10466.15 Å2
Buried surface area: 9026.97 Å2
Dissociation area: 3,775 Å2
Dissociation energy (ΔGdiss): 36.79 kcal/mol
Dissociation entropy (TΔSdiss): 22.95 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-137976

Macromolecules

Transmembrane protein gp41
Chain: A
Length: 73 amino acids
Theoretical weight: 8.5 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 546-582; Coverage: 5%)
Gene name: env
CATH: Helix Hairpins
Transmembrane protein gp41 in PDB entry 5cn0, assembly 1, front view.
Transmembrane protein gp41 in PDB entry 5cn0, assembly 1, side view.
Transmembrane protein gp41 in PDB entry 5cn0, assembly 1, top view.
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