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Crystal Structure of the P-Rex1 PH domain with Inositol-(1,3,4,5)-Tetrakisphosphate Bound

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF22697
Domain description: SOS1/NGEF-like PH domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

InterPro InterPro annotations
IPR001849
Domain description: Pleckstrin homology domain
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
IPR011993
Domain description: PH-like domain superfamily
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Structure domain

CATH CATH domain
2.30.29.30
Class: Mainly Beta
Architecture: Roll
Topology: PH-domain like
Homology: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Occurring in:
  1. Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
The deposited structure of PDB entry 5d3x contains 2 copies of CATH domain 2.30.29.30 (PH-domain like) in Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. Showing 1 copy in chain A.

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