› 5dby

X-ray diffraction
2.35Å resolution

Crystal Structure of Equine Serum Albumin in Complex with Diclofenac and Naproxen Obtained in Displacement Experiment

Released:
DOI: 10.2210/pdb5dby/pdb
PDB entry 5dby coloured by chain, front view.
PDB entry 5dby coloured by chain, side view.
PDB entry 5dby coloured by chain, top view.
Source organism: Equus caballus
Primary publication:
Structural Insights into the Competitive Binding of Diclofenac and Naproxen by Equine Serum Albumin.
Sekula B, Bujacz A
J Med Chem 59 82-9 (2016)
PMID: 26652101

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153012 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 65.63 KDa
Source organism: Equus caballus
UniProt:
  • Canonical: P35747 (Residues: 25-607; Coverage: 99%)
Gene name: ALB
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

7 bound ligands:
Ligand DIF 1 x DIF
Ligand NPS 1 x NPS
Ligand MLI 5 x MLI
Ligand SIN 1 x SIN
Ligand ACT 6 x ACT
Ligand FMT 2 x FMT
Ligand LMR 1 x LMR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P61
Unit cell:
a: 94.32Å b: 94.32Å c: 141.69Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.234

Quick links

Citations

6 citation in other articles

Structural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic properties.
Sekula et al. (2016)
5 more

3 mentions without citation

Testosterone meets albumin - the molecular mechanism of sex hormone transport by serum albumins.
Czub et al. (2019)
2 more