› 5dcl

X-ray diffraction
1.41Å resolution

Structure of a lantibiotic response regulator: N terminal domain of the nisin resistance regulator NsrR

Released:
DOI: 10.2210/pdb5dcl/pdb
PDB entry 5dcl coloured by chain, front view.
PDB entry 5dcl coloured by chain, side view.
PDB entry 5dcl coloured by chain, top view.
Source organism: Streptococcus agalactiae
Primary publication:
Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.
Khosa S, Hoeppner A, Gohlke H, Schmitt L, Smits SH
PLoS One 11 e0149903 (2016)
PMID: 26930060

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA-binding response regulator Chains: A, B
Molecule details ›
Chains: A, B
Length: 243 amino acids
Theoretical weight: 27.76 KDa
Source organism: Streptococcus agalactiae
Expression system: Escherichia coli
UniProt:
  • Canonical: X5JZS1 (Residues: 1-222; Coverage: 100%)
Gene names: AX245_04450, C4618_08650, NCTC8184_01626, graR
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand EDO 39 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 57.05Å b: 107.13Å c: 39.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.219
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches.
Patras et al. (2018)
4 more

1 mention without citation

Structure of the Response Regulator NsrR from Streptococcus agalactiae, Which Is Involved in Lantibiotic Resistance.
Khosa et al. (2016)