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Structure of Pseudomonas aeruginosa LpxA

Source organism: Pseudomonas aeruginosa PA7
Biochemical function: acyltransferase activity
Biological process: lipid A biosynthetic process
Cellular component: cytoplasm

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EC 2.3.1.129: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Reaction catalysed:
A (3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = an [acyl-carrier-protein] + a UDP-3-O-(3-hydroxyacylyl)-N-acetyl-alpha-D-glucosamine
Systematic name:
(R)-3-hydroxyacyl-[acyl-carrier-protein]:UDP-N-acetyl-alpha-D-glucosamine 3-O-(3-hydroxyacyl)transferase
Alternative Name(s):
  • (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetyl-alpha-D-glucosamine 3-O-(3-hydroxytetradecanoyl)transferase
  • (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase
  • Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
  • UDP-N-acetylglucosamine acyltransferase
  • Uridine diphosphoacetylglucosamine acyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00132
Domain description: Bacterial transferase hexapeptide (six repeats)
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
The deposited structure of PDB entry 5dem contains 12 copies of Pfam domain PF00132 (Bacterial transferase hexapeptide (six repeats)) in Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. Showing 2 copies in chain A.

PF13720
Domain description: Udp N-acetylglucosamine O-acyltransferase; Domain 2
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
The deposited structure of PDB entry 5dem contains 6 copies of Pfam domain PF13720 (Udp N-acetylglucosamine O-acyltransferase; Domain 2) in Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR010137
Domain description: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR037157
Domain description: UDP-N-acetylglucosamine O-acyltransferase, C-terminal domain superfamily
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR029098
Domain description: UDP N-acetylglucosamine O-acyltransferase, C-terminal
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR001451
Domain description: Hexapeptide repeat
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR018357
Domain description: Hexapeptide transferase, conserved site
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
IPR011004
Domain description: Trimeric LpxA-like superfamily
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

Structure domains

CATH CATH domains
1.20.1180.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Udp N-acetylglucosamine O-acyltransferase; Domain 2
Homology: Udp N-acetylglucosamine O-acyltransferase, C-terminal domain
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
The deposited structure of PDB entry 5dem contains 6 copies of CATH domain 1.20.1180.10 (Udp N-acetylglucosamine O-acyltransferase; Domain 2) in Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. Showing 1 copy in chain A.
2.160.10.10
Class: Mainly Beta
Architecture: 3 Solenoid
Topology: UDP N-Acetylglucosamine Acyltransferase; domain 1
Homology: Hexapeptide repeat proteins
Occurring in:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
The deposited structure of PDB entry 5dem contains 6 copies of CATH domain 2.160.10.10 (UDP N-Acetylglucosamine Acyltransferase; domain 1) in Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. Showing 1 copy in chain A.

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