Function and Biology

Human APE1 mismatch product complex

Source organisms:
Biochemical function: endonuclease activity
Biological process: DNA repair
Cellular component: not assigned

EC 3.1.11.2: Exodeoxyribonuclease III

Reaction catalysed:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
Systematic name:
-
Alternative Name(s):
  • E. coli exonuclease III
  • E.coli exonuclease III
  • Endoribonuclease III
  • Escherichia coli exonuclease III
  • Exonuclease III

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF03372
Domain description: Endonuclease/Exonuclease/phosphatase family
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
The deposited structure of PDB entry 5dfh contains 2 copies of Pfam domain PF03372 (Endonuclease/Exonuclease/phosphatase family) in DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004808
Domain description: AP endonuclease 1
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
IPR020848
Domain description: AP endonuclease 1, conserved site
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
IPR036691
Domain description: Endonuclease/exonuclease/phosphatase superfamily
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
IPR020847
Domain description: AP endonuclease 1, binding site
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
IPR005135
Domain description: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial

Structure domain

CATH CATH domain
3.60.10.10
Class: Alpha Beta
Architecture: 4-Layer Sandwich
Topology: Deoxyribonuclease I; Chain A
Homology: Endonuclease/exonuclease/phosphatase
Occurring in:
  1. DNA repair nuclease/redox regulator APEX1, mitochondrial
The deposited structure of PDB entry 5dfh contains 2 copies of CATH domain 3.60.10.10 (Deoxyribonuclease I; Chain A) in DNA-(apurinic or apyrimidinic site) endonuclease, mitochondrial. Showing 1 copy in chain A.