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Fc Knob-Hole Heterodimer T366W + T366S/L368A/Y407V

X-ray diffraction
1.9Å resolution
PDB entry 5di8 coloured by chain, front view.
PDB entry 5di8 coloured by chain, side view.
PDB entry 5di8 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: IG-heavy chain and peptide
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Multimeric state: hetero trimer
Accessible surface area: 21438.31 Å2
Buried surface area: 8727.7 Å2
Dissociation area: 1,061.36 Å2
Dissociation energy (ΔGdiss): 5.5 kcal/mol
Dissociation entropy (TΔSdiss): 12.91 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134816

Macromolecules

Immunoglobulin heavy constant gamma 1
Chain: A
Length: 227 amino acids
Theoretical weight: 25.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 104-328; Coverage: 56%)
  • Best match: P01857-1 (Residues: 104-330)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, top view.
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Immunoglobulin heavy constant gamma 1
Chain: B
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 104-328; Coverage: 56%)
  • Best match: P01857-1 (Residues: 104-330)
Gene name: IGHG1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, front view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, side view.
Immunoglobulin heavy constant gamma 1 in PDB entry 5di8, assembly 1, top view.
Molecule details ›

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Fc-III peptide
Chain: C
Length: 13 amino acids
Theoretical weight: 1.53 KDa
Source organism: synthetic construct
Expression system: Not provided
Fc-III peptide in PDB entry 5di8, assembly 1, front view.
Fc-III peptide in PDB entry 5di8, assembly 1, side view.
Fc-III peptide in PDB entry 5di8, assembly 1, top view.
Molecule details ›

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